P21

P21 is a synthetic tetrapeptide analogue derived from the ciliary neurotrophic factor (CNTF) sequence with a molecular weight of approximately 461.5 Da, developed as a low-molecular-weight CNS-penetrant peptidomimetic for studying CNTF receptor signaling pathways and downstream neurogenic mechanisms in laboratory research models.

Published research has studied P21 in the context of CNTF receptor pathway activation, JAK/STAT signaling modulation, and adult neurogenesis markers in preclinical models — with in vitro and in vivo findings examining effects on hippocampal neurogenesis, dendritic spine density, and spatial memory task performance in rodent models. These findings derive from laboratory study and do not describe or imply any effect in humans or animals outside of controlled research conditions.

Research has examined P21 alongside other CNS peptidomimetic research tools including Adamax (BDNF loop 4 analogue studied for TrkB pathway research) and Dihexa (HGF/MET signaling potentiator) as part of comparative neurotrophic and neurogenic pathway research designs. For further reading see: CNTF-derived peptide and neurogenesis research (PubMed).

Specifications:

• Purity: >=99% (HPLC verified)
• Form: Lyophilized powder
• Storage: −20°C

For Research Use Only. Not for human or animal consumption.