Sermorelin (GHRH 1-29 NH2) is a synthetic amidated peptide corresponding to the first 29 amino acids of endogenous human growth hormone-releasing hormone — the biologically active portion responsible for receptor binding and GH secretagogue activity at the anterior pituitary somatotrophs.
As the shortest fully active GHRH fragment, sermorelin engages GHRH receptors to stimulate GH synthesis and pulsatile secretion while remaining subject to hypothalamic negative feedback regulation — preserving the natural GH/IGF-1 axis architecture that is bypassed by exogenous GH administration.
Research models have investigated sermorelin’s effects on somatotroph function, age-related GH decline, body composition, sleep quality, and longitudinal IGF-1 axis maintenance, with its physiological feedback preservation making it a preferred research compound for GH axis studies where axis integrity is an experimental variable.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
P. Jensen –
Solid Sermorelin. Arrived in 3 days, well packaged, COA confirmed purity. Switched over from another supplier after Peptide Sciences closed and AminoForge has been seamless.