Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a small peptidomimetic derived from angiotensin IV that acts as a potent positive allosteric modulator of hepatocyte growth factor (HGF) binding to its receptor c-Met — a receptor tyrosine kinase signaling axis that plays a central role in synaptogenesis, neuronal survival, dendritic arborization, and cognitive function in the central nervous system.
Research has demonstrated that Dihexa enhances HGF/c-Met signaling with potency estimated to exceed brain-derived neurotrophic factor (BDNF) by several orders of magnitude in synaptic formation assays, producing measurable improvements in spatial memory, object recognition, and cognitive performance in rodent models of cognitive deficit, ischemic injury, and Parkinson’s disease.
Its unique mechanism as an HGF potentiator — rather than a direct receptor agonist — and its ability to penetrate the blood-brain barrier make Dihexa a distinctive and highly studied research compound for neurotrophic factor biology, synaptic plasticity, and cognitive neuroscience.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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