SNAP-8 (acetyl octapeptide-3; Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2) is a synthetic octapeptide analog of the N-terminal fragment of SNAP-25 — a core component of the SNARE protein complex responsible for mediating acetylcholine vesicle fusion and neurotransmitter release at the neuromuscular junction — studied for its ability to compete with SNAP-25 and modulate neuromuscular signal transduction in research models.
By interfering with SNARE complex assembly in a dose-dependent manner, SNAP-8 attenuates acetylcholine release at the neuromuscular junction, reducing muscle contraction intensity in a mechanism analogous to but distinct from botulinum toxin — without enzymatic cleavage of SNARE proteins.
Research has examined SNAP-8’s applications in neuromuscular biology, synaptic vesicle fusion mechanics, cosmetic peptide pharmacology, and the study of SNARE-dependent secretory pathway modulation — with its targeted and reversible mechanism making it a valuable tool for controlled neurotransmission research.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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