KPV

KPV (Lys-Pro-Val) is a naturally occurring tripeptide comprising the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH) — the minimal bioactive fragment that retains the parent molecule’s full anti-inflammatory potency while eliminating its melanotropic and broader hormonal effects.

KPV exerts its anti-inflammatory activity through dual mechanisms: direct inhibition of NF-κB and MAPK signaling pathway activation — suppressing pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β) and reducing adhesion molecule expression — and cellular uptake via the PepT1 dipeptide/tripeptide transporter expressed on intestinal epithelial and immune cells, enabling direct intracellular anti-inflammatory action independent of melanocortin receptor engagement.

Preclinical research has demonstrated KPV’s efficacy in models of inflammatory bowel disease, ulcerative colitis, dermal wound healing, corneal re-epithelialization, airway inflammation, and oxidative stress-induced keratinocyte injury — establishing it as a highly selective and mechanistically well-characterized research tool for studying peptide-mediated inflammation resolution across gastrointestinal, dermal, and pulmonary tissue systems.

Specifications:

• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: −20°C

For Research Use Only.