5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme highly expressed in adipose tissue and liver that consumes SAM (S-adenosylmethionine) to methylate nicotinamide, simultaneously depleting methyl donor pools and reducing NAD+ precursor availability in a manner that promotes adipogenesis and metabolic dysfunction.
By selectively inhibiting NNMT, 5-Amino-1MQ has demonstrated the ability to raise intracellular NAD+ and SAM levels, activate SIRT1, reduce adipocyte differentiation, decrease lipid accumulation, and produce significant fat mass reduction without caloric restriction in preclinical rodent models.
Research has examined its applications in obesity, metabolic syndrome, type 2 diabetes, and NAD+ biology, with its novel NNMT inhibition mechanism representing a distinct and complementary approach to metabolic research compared to direct NAD+ precursor supplementation.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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