ARA-290 is an 11-amino acid cyclic peptide engineered from the helix B region of erythropoietin (EPO) — specifically designed to engage the innate repair receptor (IRR, a heterodimer of the EPO receptor and the beta common receptor) without activating the classical EPO hematopoietic receptor — thereby selectively triggering tissue-protective and anti-inflammatory signaling while avoiding the erythropoietic and thrombotic liabilities of native EPO.
Through IRR activation, ARA-290 has demonstrated potent anti-inflammatory, neuroprotective, and metabolic effects in preclinical models — reducing pro-inflammatory cytokine production, protecting neurons from apoptosis, improving peripheral nerve function, normalizing autonomic dysfunction, and enhancing beta-cell survival in pancreatic stress models.
Research applications have spanned small fiber neuropathy, sarcoidosis, diabetic complications, ischemic organ protection, and inflammatory disease — positioning ARA-290 as a precision tissue-protective research compound with a uniquely favorable receptor selectivity profile.
Reconstitute using Phosphate-buffered saline (PBS) instead of Bacteriostatic Water for best results.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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