CJC-1295 without DAC (also known as Mod GRF 1-29) is a truncated and stabilized analog of growth hormone-releasing hormone (GHRH), comprising the biologically active first 29 amino acids of the native 44-residue peptide with four strategic amino acid substitutions to resist DPP-IV cleavage and extend receptor binding duration.
Unlike the DAC-conjugated variant, this form produces discrete, physiologically patterned GH pulses rather than sustained elevation — making it the preferred tool for research requiring pulsatile GH secretion modeling that closely mimics endogenous hypothalamic-pituitary dynamics.
Studies have examined CJC-1295 (no DAC) in the context of GH axis characterization, body composition research, IGF-1 axis signaling, sleep-related GH release, and its synergy with GHRPs like ipamorelin in amplifying GH pulse amplitude without desensitization.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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