Follistatin 344 (FS-344) is a 344-amino acid isoform of the endogenous glycoprotein follistatin with a molecular weight of approximately 37 kDa, characterized by its high-affinity binding and neutralization of activin, myostatin (GDF-8), and other members of the TGF-β superfamily — acting as a potent endogenous antagonist of these ligands by forming non-signaling complexes that prevent receptor binding and downstream SMAD2/3 signaling pathway activation in target tissues.
The FS-344 isoform is distinguished by its heparin-binding domain, which mediates cell surface and extracellular matrix association in target tissues — with research demonstrating that this tissue-binding profile concentrates its antagonist activity locally at sites of expression, making it a particularly useful research tool for investigating tissue-specific roles of activin and myostatin signaling in skeletal muscle biology, reproductive axis regulation, and bone metabolism in preclinical models.
Research has focused on Follistatin 344’s role as a myostatin and activin antagonist in skeletal muscle hypertrophy models, its regulatory function in the hypothalamic-pituitary-gonadal axis through FSH suppression, and its broader role in TGF-β superfamily signaling biology — with its mechanism complementing IGF-1 LR3 & MOTS-C.
For further reading see: Follistatin myostatin antagonism and muscle biology research (PubMed).
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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