IGF-1 LR3 (Insulin-like Growth Factor-1 Long Arg3) is a recombinant analog of human IGF-1 featuring an N-terminal 13-amino acid extension and an Arg3 substitution that dramatically reduces IGF binding protein (IGFBP) affinity, extending its biological half-life from minutes to approximately 20–30 hours and substantially increasing its systemic bioavailability compared to native IGF-1.
As a potent activator of the IGF-1 receptor (IGF-1R) and downstream PI3K/Akt/mTOR signaling, IGF-1 LR3 promotes cellular proliferation, differentiation, survival, and protein synthesis while inhibiting apoptosis across a broad range of tissue types in research models.
Studies have examined its effects on skeletal muscle hypertrophy, satellite cell activation, adipose tissue modulation, neurotropic support, and cartilage/bone anabolic signaling — establishing IGF-1 LR3 as an essential research tool for growth factor biology, tissue engineering, and anabolic pathway mechanistic studies.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
Dr. K. Patel –
IGF-1 LR3 is exactly what I needed. Documentation is thorough, purity confirmed, and the concierge team helped me with my order. Excellent supplier.