SS-31

SS-31 (D-Arg-Dmt-Lys-Phe-NH2) is a mitochondria-targeted tetrapeptide that selectively concentrates in the inner mitochondrial membrane by electrostatic interaction with cardiolipin — a phospholipid essential for electron transport chain organization and mitochondrial cristae integrity.

By stabilizing cardiolipin and reducing mitochondrial reactive oxygen species (ROS) production, SS-31 has demonstrated the ability to restore mitochondrial membrane potential, improve ATP synthesis efficiency, reduce apoptotic signaling, and attenuate ischemia-reperfusion injury in multiple preclinical organ systems.

Research models have examined SS-31’s protective effects in cardiac, renal, neuronal, and skeletal muscle tissue, with particular interest in its applications for age-related mitochondrial dysfunction, metabolic disease, heart failure, and neurodegenerative research — positioning it as a premier tool for mitochondria-targeted mechanistic studies.

Specifications:

• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: −20°C

For Research Use Only.