SLU-PP-332

SLU-PP-332 is a synthetic small-molecule agonist of estrogen-related receptors alpha and gamma (ERRα/ERRγ) — nuclear receptors that function as master transcriptional regulators of mitochondrial biogenesis, oxidative metabolism, and fatty acid oxidation gene programs — designed to pharmacologically mimic the metabolic adaptations of endurance exercise at the cellular level.

By activating ERRα and ERRγ, SLU-PP-332 drives expression of PGC-1α-dependent gene networks governing mitochondrial proliferation, slow-twitch muscle fiber development, GLUT4 expression, and beta-oxidation capacity — producing measurable improvements in exercise endurance, metabolic flexibility, and fat utilization in preclinical rodent models without physical training.

Research has examined SLU-PP-332 in the context of exercise biology, obesity, heart failure, skeletal muscle atrophy, and metabolic syndrome — with its mechanism as an “exercise mimetic” establishing it as a novel research tool for studying ERR-mediated metabolic transcription independent of traditional exercise interventions.

Reconstitute using Dimethyl sulfoxide (DMSO) prior to adding Bacteriostatic Water for best results.

Specifications:

• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: −20°C

For Research Use Only.