FOXO4-DRI is a D-amino acid retro-inverso peptide derived from the FOXO4 transcription factor, engineered to penetrate cells and disrupt the interaction between FOXO4 and the tumor suppressor p53 — a binding interaction that is upregulated in senescent cells to sequester p53 and prevent the initiation of apoptosis, enabling senescent cell survival and the perpetuation of the senescence-associated secretory phenotype (SASP).
By competitively inhibiting this FOXO4-p53 interaction, FOXO4-DRI restores p53’s pro-apoptotic function specifically in senescent cells, triggering their selective clearance without affecting healthy proliferating or quiescent cell populations in preclinical models.
Research in aged and fast-aging mouse models has demonstrated that FOXO4-DRI administration results in reduced senescent cell burden, restoration of fur density, improved renal function, enhanced exercise capacity, and extended healthspan — establishing it as a highly targeted senolytic research tool for aging and cellular senescence studies.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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