Kisspeptin-10 is the biologically active C-terminal decapeptide (amino acids 112–121) derived from the KISS1 gene product, with a molecular weight of approximately 1,302.5 Da. As the minimal active fragment of kisspeptin that retains full agonist activity at the KISS1 receptor (GPR54), Kisspeptin-10 activates Gq/11-coupled intracellular signaling to drive IP3-mediated calcium mobilization and downstream depolarization of hypothalamic GnRH neurons — making it a precisely defined pharmacological tool for studying the kisspeptin/GPR54 axis in neuroendocrine research.
Identified as the key regulator of the hypothalamic-pituitary-gonadal (HPG) axis, Kisspeptin-10 has been studied extensively for its role in GnRH pulse generation, LH and FSH secretion dynamics, and the neuroendocrine integration of metabolic and reproductive signaling — with research in preclinical models examining its effects on GnRH neuron firing patterns, gonadotropin release kinetics, and the relationship between kisspeptin signaling and puberty onset, reproductive cyclicity, and energy homeostasis.
Research has focused on Kisspeptin-10’s role as a master regulator of reproductive neuroendocrinology — with its direct GPR54 agonism and defined minimal active sequence making it the standard research tool for kisspeptin axis studies alongside GH-axis compounds such as Tesamorelin and CJC-1295 No DAC for comprehensive neuroendocrine axis research. For further reading see: Kisspeptin GPR54 axis and GnRH regulation research (PubMed).
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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