Semax is a synthetic heptapeptide derived from the ACTH(4-7) sequence (Met-Glu-His-Phe) with a Pro-Gly-Pro C-terminal extension that confers resistance to enzymatic degradation and enhanced CNS penetration.
Originally developed in Russia for stroke and cognitive research, Semax has been extensively studied for its ability to upregulate BDNF, NGF, and VEGF expression in hippocampal and cortical neurons, activate serotonergic and dopaminergic systems, and exert potent neuroprotective effects against ischemic injury in animal models.
Research has focused on its mechanisms in memory consolidation, attention and executive function enhancement, neuroplasticity promotion, and neuroinflammation reduction — with its unique ability to rapidly modulate neurotrophic factor gene expression making it a valuable tool for studying acute and chronic neuroregenerative pathways.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
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