Nicotinamide Adenine Dinucleotide (NAD+) is an essential pyridine nucleotide coenzyme that serves as the central electron carrier in cellular energy metabolism and as a critical substrate for a family of NAD+-consuming enzymes — including sirtuins (SIRT1-7), poly(ADP-ribose) polymerases (PARPs), and cyclic ADP-ribose synthases — that regulate DNA repair, gene expression, mitochondrial biogenesis, and stress response pathways.
NAD+ levels decline significantly with age across multiple tissues, and this decline is mechanistically linked to reduced mitochondrial function, impaired sirtuin-mediated gene regulation, diminished DNA repair capacity, and increased inflammation — positioning NAD+ repletion as a central target in longevity and metabolic disease research.
Preclinical studies have demonstrated that NAD+ restoration improves muscle function, cognitive performance, metabolic flexibility, DNA damage repair, and lifespan parameters across multiple aging model organisms.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
T. Brooks –
NAD+ quality is outstanding. Purity verified, fast shipping, and the free bacteriostatic water on my order was a nice bonus. AminoForge has earned a loyal customer.