Peptide Receptor Modulator Research Series — Amylin Receptor Agonist Investigational Compound.
AMA-37-C18 is a long-acting acylated amylin analog engineered through structural modification of human amylin with C18 fatty acid acylation for extended plasma half-life and once-weekly dosing suitability in longitudinal research models. It selectively activates amylin receptors (AMY1-3) expressed in the area postrema, nucleus tractus solitarius, and hypothalamus — brain regions involved in energy homeostasis, gastric motility regulation, and glucoregulatory signaling.
As a selective amylin receptor agonist, AMA-37-C18 engages distinct receptor populations from GLP-1R agonists, providing a mechanistically orthogonal tool for investigating amylin pathway contributions to metabolic regulation. Research models have examined its applications across appetite signaling, gastric emptying, glycemic parameters, and combinatorial incretin-amylin receptor co-activation studies.
Product Specifications
| CAS Number | 2450271-88-0 |
| Molecular Weight | ~4,198 g/mol |
| Amino Acid Count | 37 |
| Purity | ≥99% by HPLC | COA available |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in bacteriostatic water; consult COA for specific solvent recommendations |
| Storage Conditions | Store at −20°C; protect from light and moisture |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures.
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