Peptide Receptor Modulator Research Series — Single Agonist Investigational Compound.
SIA-31-C18 is a synthetic 31-amino acid GLP-1 receptor agonist with approximately 94% sequence homology to native human GLP-1, modified by an Aib substitution at position 8 and a C18 fatty diacid acylation at position 26 via a γ-Glu/OEG linker. It is a frequent subject of laboratory research and is supplied as a lyophilized powder for research use only.
In published in vitro research, SIA-31-C18 has been studied in connection with GLP-1 receptor (GLP-1R) binding and cyclic AMP (cAMP) signaling. These studies are conducted in cell-culture and receptor-assay research models. The findings derive from laboratory research and do not describe or imply any effect, benefit, or use in humans or animals.
Its receptor mechanism is studied alongside related research compounds such as Dual Regulator and Amylin Analog.
For further reading, see published research on GLP-1 receptor agonists on PubMed.
Product Specifications
| CAS Number | 910463-68-2 |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | ~4,113.6 g/mol |
| Amino Acid Count | 31 |
| Amino Acid Sequence | His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 fatty diacid via γ-Glu-2×OEG linker)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-NH₂ |
| Synonyms | Semaglutide (research analog), GLP-1R agonist research class, NNC-0113-0217 |
| Purity | ≥99% by HPLC | COA available |
| Physical Form | Lyophilized powder |
| Storage Conditions | Store at −20°C; protect from light and moisture |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures. This product is sold exclusively for in-vitro laboratory research use. It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S. Food and Drug Administration for any use. Not intended to diagnose, treat, cure, mitigate, or prevent any disease. Not for human or animal consumption.
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