Peptide Receptor Modulator Research Series — Triple Agonist Investigational Compound.
TIA-39-C20 is a synthetic 39-amino acid triple receptor agonist built on a GIP peptide backbone, modified for co-engagement of the GLP-1 receptor (GLP-1R), GIP receptor (GIPR), and glucagon receptor (GCGR), with non-coded residue substitutions at positions 2, 13, and 20 and a C20 fatty diacid conjugate. It is a frequent subject of laboratory research and is supplied as a lyophilized powder for research use only.
In published in vitro research, TIA-39-C20 has been studied in connection with binding at GLP-1R, GIPR, and GCGR and associated cyclic AMP (cAMP) signaling. These studies are conducted in cell-culture and receptor-assay research models. The findings derive from laboratory research and do not describe or imply any effect, benefit, or use in humans or animals.
Its receptor mechanism is studied alongside related research compounds such as Dual Regulator, Single Regulator, and Amylin Analog.
For further reading, see published research on incretin receptor agonists on PubMed.
Product Specifications
| CAS Number | 2381089-83-2 |
| PubChem CID | 171390338 |
| Molecular Formula | C₂₂₁H₃₄₂N₄₆O₆₈ |
| Molecular Weight | ~4,731 g/mol |
| Amino Acid Count | 39 |
| Amino Acid Sequence | Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-(α-Me-Leu)-Leu-Asp-Lys(C20 diacid via γ-Glu-AEEA linker)-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂ |
| Synonyms | Retatrutide (research analog), GLP-1R/GIPR/GCGR triple-agonist research class, LY-3437943 |
| Purity | ≥99% by HPLC | COA available |
| Physical Form | Lyophilized powder |
| Storage Conditions | Store at −20°C; protect from light and moisture |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures. This product is sold exclusively for in-vitro laboratory research use. It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S. Food and Drug Administration for any use. Not intended to diagnose, treat, cure, mitigate, or prevent any disease. Not for human or animal consumption.
Marcus T. –
Exceptional quality and fast shipping. Received my order within 3 days and the COA confirmed 99.4% purity — exactly as advertised. Will be ordering again.