TB-500 is a synthetic peptide derived from the actin-binding domain of thymosin beta-4 (Tβ4) — a naturally occurring 43-amino acid polypeptide ubiquitously expressed in mammalian cells and found in high concentrations at wound sites and in platelets — engineered to replicate and amplify the parent molecule’s regenerative and cytoprotective properties.
Its primary mechanism of action involves G-actin sequestration: TB-500 binds monomeric G-actin with high affinity, regulating the equilibrium between monomeric and filamentous actin and enabling rapid cytoskeletal reorganization that drives directed cell migration of fibroblasts, keratinocytes, endothelial cells, and progenitor cells into injured tissue sites.
Beyond cytoskeletal modulation, TB-500 promotes angiogenesis through integrin-linked kinase (ILK) and Akt pathway activation, upregulates matrix metalloproteinase production to facilitate basement membrane remodeling, inhibits NF-κB-dependent inflammatory signaling, and activates epicardial progenitor cell mobilization — with preclinical research across wound healing, cardiac tissue repair, corneal re-epithelialization, musculoskeletal recovery, and neurological protection models establishing it as one of the most mechanistically versatile regenerative peptides in current research.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
A. Patel –
Great purity, great price. Been looking for a reliable supplier and AminoForge has delivered on every front. Fast shipping, thorough documentation, and competitive pricing. Happy with everything so far.