VIP

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide belonging to the secretin/glucagon superfamily, widely distributed throughout the central and peripheral nervous systems, gastrointestinal tract, and immune tissues, where it functions as a pleiotropic neuroimmune mediator with potent anti-inflammatory, vasodilatory, and immunomodulatory properties.

Through high-affinity binding to VPAC1 and VPAC2 receptors and downstream cAMP/PKA signaling, VIP suppresses pro-inflammatory cytokine production (TNF-α, IL-6, IL-12), promotes Th2 and regulatory T-cell differentiation, relaxes smooth muscle, enhances mucosal barrier integrity, and modulates circadian rhythms via SCN receptor activation.

Research has investigated VIP across a wide range of applications including pulmonary arterial hypertension, inflammatory bowel disease, autoimmune conditions, COVID-19-related inflammation, neuroprotection, and circadian rhythm disorders — with its combination of immunoregulatory and vasoactive properties making it a uniquely multifunctional research compound.

Specifications:

• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: −20°C

For Research Use Only.