Peptide Receptor Modulator Research Series — Triple Agonist Investigational Compound.
TIA-39-C20 is a synthetic 39-amino acid triple receptor agonist engineered for simultaneous co-activation of the GLP-1 receptor (GLP-1R), GIP receptor (GIPR), and glucagon receptor (GCGR) — representing a mechanistically distinct approach from dual incretin agonists through the addition of glucagon receptor engagement. Each receptor component contributes discrete downstream signaling: GLP-1R activation influences insulin secretion dynamics and gastric motility; GIPR engagement modulates incretin-mediated insulin response and lipid metabolism; GCGR activation drives hepatic glucose output regulation, fatty acid oxidation, and thermogenic signaling pathways.
Research models have examined TIA-39-C20 across metabolic regulation, glycemic parameters, hepatic lipid accumulation, body composition, cardiovascular markers, and MASH-related fibrotic pathways — with particular interest in the additive and synergistic effects of triple receptor co-activation compared to mono- and dual-agonist reference compounds.
Product Specifications
| CAS Number | 2381524-34-9 |
| Molecular Formula | C₂₁₉H₃₄₂N₄₈O₆₅ |
| Molecular Weight | 4,755.3 g/mol |
| Amino Acid Count | 39 |
| Purity | ≥99% by HPLC | COA available |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in bacteriostatic water; consult COA for specific solvent recommendations |
| Storage Conditions | Store at −20°C; protect from light and moisture |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures. This product is sold exclusively for in-vitro laboratory research use. It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S. Food and Drug Administration for any use. Not intended to diagnose, treat, cure, mitigate, or prevent any disease. Not for human or animal consumption.
Marcus T. –
Exceptional quality and fast shipping. Received my order within 3 days and the COA confirmed 99.4% purity — exactly as advertised. Will be ordering again.