MOTS-c is a 16-amino acid mitochondrial-derived peptide (MDP) encoded within the 12S rRNA region of the mitochondrial genome, representing a newly identified class of bioactive molecules that bridge mitochondrial function and systemic metabolic regulation.
Upon exercise or metabolic stress, MOTS-c translocates from mitochondria to the nucleus where it activates AMPK signaling, regulates AICAR-dependent folate cycle flux, and modulates the expression of nuclear genes governing glucose uptake, fatty acid oxidation, and oxidative stress response.
Research has demonstrated MOTS-c’s ability to improve insulin sensitivity, enhance skeletal muscle glucose metabolism, counteract diet-induced obesity, and extend lifespan in aged mouse models — establishing it as a key research target in metabolic disease, exercise biology, longevity science, and the emerging field of mitochondrial-nuclear communication.
Specifications:
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Storage: −20°C
For Research Use Only.
Dr. Linda M. –
MOTS-C from AminoForge is top notch. Purity confirmed by the COA and reconstitution was flawless. Shipping was fast and packaging completely discreet. Will be a repeat customer.