Peptide Receptor Modulator Research Series — Single Agonist Investigational Compound.
SIA-31-C18 is a synthetic 31-amino acid GLP-1 receptor agonist with 94% sequence homology to endogenous human GLP-1, engineered through strategic amino acid substitution at position 8 (Ala→Aib) to confer DPP-4 resistance, and C18 fatty diacid acylation at position 26 enabling albumin binding and extended plasma half-life (~7 days) suitable for once-weekly dosing protocols in longitudinal research models.
As a selective GLP-1R agonist, SIA-31-C18 activates cAMP-mediated signaling pathways influencing glucose-dependent insulin secretion, glucagon suppression, gastric motility modulation, and hypothalamic receptor engagement. Research models have examined its applications across metabolic regulation, glycemic parameters, hepatic lipid accumulation, cardiovascular markers, and CNS receptor signaling.
Product Specifications
| CAS Number | 910463-68-2 |
| Molecular Formula | C₁₈₇H₂₉₁N₄₅O₅₉ |
| Molecular Weight | 4,113.58 g/mol |
| Amino Acid Count | 31 |
| Amino Acid Sequence | His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(C18 fatty diacid via γ-Glu-2×OEG linker)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-NH₂ |
| Purity | ≥99% by HPLC | COA available |
| Physical Form | Lyophilized powder |
| Solubility | Soluble in bacteriostatic water; consult COA for specific solvent recommendations |
| Storage Conditions | Store at −20°C; protect from light and moisture |
For Research Use Only. Not for use in diagnostic, therapeutic, or human or animal in-vivo procedures. This product is sold exclusively for in-vitro laboratory research use. It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S. Food and Drug Administration for any use. Not intended to diagnose, treat, cure, mitigate, or prevent any disease. Not for human or animal consumption.
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